Role of Tranexamic Acid in Oral Surgery

Abstract

Background: Tranexamic acid is a synthetic lysine derivative that exerts its antifibrinolytic effect by

reversibly blocking lysine binding sites on plasminogen and thus preventing fibrin degradation. In case of

dental surgery, post operative bleeding is a common problem which if uncontrolled can result in increased

loss of blood and delayed wound healing. Patients with bleeding and clotting disorders and patients on anti

coagulant therapy have tendency for excessive bleeding. In such cases the use of tranexamic acid becomes

more significant in dental surgeries. By understanding the pharmacokinetics and pharmacodynamic aspects

of the tranexamic acid we can gain a through knowledge about its properties which will aid its use in oral

surgery.