Effect of Non- Surgical Periodontal Therapy on Plasma Homocysteine Levels in Patients with Chronic Periodontitis- A Prospective Study
DOI:
https://doi.org/10.37506/ijphrd.v11i6.9749Keywords:
Chronic Periodontitis, Root planning, Scaling, Homocysteine, PlasmaAbstract
Background: The aim of the study was to evaluate and correlate the effect of non surgical periodontal
therapy on homocysteine levels in patients with chronic periodontitis.
Methods: Fifty participants were enrolled in the study (n=50) in the age range of 20-45 yrs. Each patient
was examined using a mouth mirror and UNC-15 graduated periodontal probe. After recording the clinical
parameters & indices (CAL, OHI-S, GI), venous blood was drawn from the antecubital vein and transferred
to a vial and centrifuged to isolate the plasma, which was then sent for evaluation of plasma homocysteine
level. Non-surgical therapy was performed which consisted of scaling and root planing (SRP). After 90 days,
the patient was re-evaluated for clinical parameters and the readings were recorded again. Blood samples
were sent for analysis of post treatment plasma homocysteine levels.
Results: The plasma Hcy level in periodontitis subjects during pre treatment was 20.7± 3.4 µmol/L which
was significantly higher. Post therapy levels reduced to 14.7± 2.2 µmol/L. The OHI’s and GI were also
significantly reduced after post therapy.
Conclusion: An inflammatory condition like chronic periodontitis is significantly associated with elevated
plasma homocysteine levels. However, no significant change was seen in the plasma homocysteine levels
between males and females. Periodontal intervention shows statistically significant improvement in plasma
homocysteine values.
