Tithonia Diversifolia vs Catechin: Role in Regulating Blood Glucose, Malondialdehyd, and Super Oxide Dismutase Level on Rat Induced Diabetes Mellitus and High-Fat Diet

Abstract

Tithonia diversifolia (TD) is known as medicine plant which contains antioxidants and has been known as anti-diabetic medicine. Diabetic patient has increased blood glucose, reactive oxygen species (ROS), and malondialdehyd (MDA) level. In other side, the super oxide dismutase (SOD) level commonly attenuates. The aims of this study was to analyze the effect of Tithonia diversifolia and catechin in blood glucose, malondialdehyd (MDA), and Super Oxide Dismutase (SOD) level on diabetic and high fat induced rats. The design of this study was Randomized Posttest Control Group Design using Wistar strain rats which were divided into 4 groups. After treatment, all groups of rats were sacrificed to take blood samples then measured blood glucose, MDA and SOD level. Statistical analysis of data to examine differences in treatment and control was conducted by one way Anova test with a 95% confidence level (?=0.05). There was difference of glucose level (p=0.020) between control and treatment groups, but there were no differences in MDA level (p=0.103) and SOD level (p=0.207).