Evaluation of Malondialdehyde, Glutathione Peroxidase and Defensin Levels in Patients with and without Periodontitis

Abstract

Aim: Aim of the study is to estimate the levels of Malondialdehyde, glutathione peroxidase and Defensin levels on patients with and without periodontitis. Materials and Method: The levels of Malondialdehyde and Glutathione peroxidase was estimated using colorimetric estimation and Defensin was estimated using ELISA Results: Levels of Defensin is increased in patients with periodontitis 9.18+-1.72 when compared to healthy subjects 6.22+-2.73. The mean levels of MDA is increased in patients with periodontitis 2.35+-0.32 when compared to normal patients 3.58+-0.36. The levels of Gpx is lower in patients with periodontitis 2.52+-0.58 when compared to normal patients 3.58+-0.36. The p – value was found to be significant (0.001) Conclusion: Thus, this study reveals that Malondialdehyde, Defensin and glutathione peroxidase can be considered as biomarkers in the periodontal diseases.