Agricultural Chemical Exposure and Worker Health: An Epidemiological Review
DOI:
https://doi.org/10.37506/5sc9qq83Keywords:
Agrochemicals , Agriculture, Occupational health, Epidemiology, ToxicologyAbstract
Agricultural workers are susceptible to a range of chemicals, such as pesticides, fertilizers, and other agrochemicals, which pose significant risks to their health. Understanding the epidemiology of exposure to these chemical hazards is crucial for developing effective preventive strategies and improving occupational health standards among agricultural workers. The review aims to synthesize existing research on the prevalence, types, and health effects of chemical exposures among agricultural workers. The prevalence of chemical exposures was high, with significant regional variations. Health effects ranged from acute symptoms like skin irritation and respiratory issues to chronic conditions such as cancer, neurotoxicity, and reproductive problems. Several studies highlighted the increased vulnerability of certain subgroups, including women, children, and migrant workers. Additionally, the review found that chemical hazards not only impact human health but also pose serious threats to environmental safety, leading to soil degradation, water contamination, and biodiversity loss. There is a critical need for enhanced regulatory measures, improved safety practices, and targeted interventions to mitigate these risks. Furthermore, the environmental impact of these chemicals underscores the necessity for sustainable agricultural methods that protect both human well-being and the ecosystem. Future research must assess combined chemical exposures and preventive strategies across agricultural settings.
References
Praburaj L, Design F, Nadu T. Role of agriculture in the economic development of a country. Shanlax International Journal of Commerce. 2018 Jul;6(3):1-5.
Khode D, Hepat A, Mudey A, Joshi A. Health-related challenges and programs among agriculture workers: a narrative review. Cureus. 2024 Mar;16(3).
Alston JM, Pardey PG. Agriculture in the global economy. Journal of Economic Perspectives. 2014 Feb 1;28(1):121-46.
Tudi M, Daniel Ruan H, Wang L, Lyu J, Sadler R, Connell D, Chu C, Phung DT. Agriculture development, pesticide application and its impact on the environment. International journal of environmental research and public health. 2021 Feb;18(3):1112.
Nayak P, Solanki H. Pesticides and Indian agriculture—a review. Int J Res Granthaalayah. 2021 Jun 4;9(5):250-63.
Gill HK, Garg H. Pesticide: environmental impacts and management strategies. Pesticides-toxic aspects. 2014 Feb 20;8(187):10-5772.
Ghafari M, Cheraghi Z, Doosti-Irani A. Occupational risk factors among Iranian farmworkers: a review of the available evidence. Epidemiology and health. 2017;39.
Hernández AF, Gómez MA, Pérez V, García-Lario JV, Pena G, Gil F, López O, Rodrigo L, Pino G, Pla A. Influence of exposure to pesticides on serum components and enzyme activities of cytotoxicity among intensive agriculture farmers. Environmental research. 2006 Sep 1;102(1):70-6.
Kumar D, Sinha SN, Vasudev K, Kumar R, Balaji G, Mungamuri SK, Validandi V. Biomonitoring of pesticide exposure and its health implications in agricultural areas of Telangana, India: A brief data report. Data in Brief. 2024 Aug 1;55:110632.
Directorate of Plant Protection Quarantine & Storage. 2019. “IPM at A Glance.” https://ppqs.gov.in/divisions/integrated-best-management/ibm-glance
Subash SP, Chand P, Pavithra S, Balaji SJ, Pal S. Pesticide use in Indian agriculture: Trends, market structure and policy issues (Policy brief, ICAR–National institute of agricultural economics and policy research). New Delhi: Indian Council of Agricultural Research. 2017.
de-Assis MP, Barcella RC, Padilha JC, Pohl HH, Krug SB. Health problems in agricultural workers occupationally exposed to pesticides. Revista Brasileira de Medicina do Trabalho. 2020 Jul;18(3):352.
Damalas CA, Koutroubas SD. Farmers’ exposure to pesticides: toxicity types and ways of prevention. Toxics. 2016 Jan 8;4(1):1.
Insecticides/pesticides registered under section 9(3) of the insecticides act, for 1968 for use in the country.2021
Ehlers JK, Connon C, Themann CL, Myers JR, Ballard T. Health and safety hazards associated with farming. AAOHN journal. 1993 Sep;41(9):414-21.
Steenland K, Jenkins B, Ames RG, O'Malley M, Chrislip D, Russo J. Chronic neurological sequelae to organophosphate pesticide poisoning. American Journal of Public Health. 1994 May;84(5):731-6.
Mesnage R, Székács A, Zaller JG. Herbicides: Brief history, agricultural use, and potential alternatives for weed control. In Herbicides 2021 Jan 1 (pp. 1-20). Elsevier.
Jamaludheen A, Singh PK, Gharde Y. Production trend of herbicides vis-Ã-vis other pesticides in India. Indian Farming.;72(1).
Grover R, Cessna A. Environmental chemistry of herbicides. CRC press; 1990 Nov 21.
Sapkota R, Stenger J, Ostlie M, Flores P. Towards reducing chemical usage for weed control in agriculture using UAS imagery analysis and computer vision techniques. Scientific Reports. 2023 Apr 21;13(1):6548.
Thind TS. Role of fungicides in crop health management: prospects and challenges. Developments in Fungal Biology and Applied Mycology. 2017:433-47.
Thind TS. Fungicides in crop health security–the road ahead. Indian Phytopath. 2012;165(2):10.
Rani R, Kaur A, Chhabra R, Jain S. Role of fungicides in agriculture and their impact on environment: a review. Plant Arch. 2024;24(1):1013–23.
Lini RS, Scanferla DT, de Oliveira NG, Aguera RG, Santos TD, Teixeira JJ, Kaneshima AM, Mossini SA. Fungicides as a risk factor for the development of neurological diseases and disorders in humans: a systematic review. Critical Reviews in Toxicology. 2024 Jan 2;54(1):35-54.
Shukla AK, Behera SK, Chaudhari SK, Singh G. Fertilizer use in Indian agriculture and its impact on human health and environment. Indian J Fertil. 2022 Mar;18(3):218-37.
FAI. 2020. Fertiliser Statistics 2019-20, 65th Edition. The Fertiliser Association of India, New Delhi.
Chakraborty S, Mandal M, Chakraborty AP, Majumdar S. Zinc solubilizing rhizobacteria as soil health engineer managing zinc deficiency in plants. In Rhizosphere Engineering 2022 Jan 1 (pp. 215-238). Academic Press.
Aktar W, Sengupta D, Chowdhury A. Impact of pesticides use in agriculture: their benefits and hazards. Interdisciplinary toxicology. 2009 Mar 1;2(1):1-2.
Banerjee S, Gangopadhyay D, Roy R, Dimitrov SE, Chatterjee S. Pesticide Poisoning in India: A Major Public Health Issue and its Antidotes. Scientific Reports.;5(1):27-38.
Thundiyil JG, Stober J, Besbelli N, Pronczuk J. Acute pesticide poisoning: a proposed classification tool. Bulletin of the World Health Organization. 2008;86:205-9.
Koli P, Bhardwaj NR. Status and use of pesticides in forage crops in India. Journal of pesticide science. 2018 Nov 20;43(4):225-32.
Gupta PK. Pesticide exposure—Indian scene. Toxicology. 2004 May 20;198(1-3):83-90.
Hundekari IA, Suryakar AN, Dongre N, Rathi DB. Acute poisoning with organophosphorus pesticide: Patients admitted to a hospital in bijapur, Karnataka.
Mittal C, Singh S, Kumar-M P, Varthya SB. Toxicoepidemiology of poisoning exhibited in Indian population from 2010 to 2020: a systematic review and meta-analysis. BMJ open. 2021 May 1;11(5):e045182.
Arcury TA, Quandt SA. Chronic agricultural chemical exposure among migrant and seasonal farmworkers. Society & Natural Resources. 1998 Dec 1;11(8):829-43.
Zahm SH, Ward MH, Blair A. Pesticides and cancer. Occupational Medicine-State of the Art Reviews. 1997 Apr 1;12(2):269-90.
Cuenca JB, Tirado N, Barral J, Ali I, Levi M, Stenius U, Berglund M, Dreij K. Increased levels of genotoxic damage in a Bolivian agricultural population exposed to mixtures of pesticides. Science of the Total Environment. 2019 Dec 10;695:133942.
Andreotti G, Freeman LE, Hou L, Coble J, Rusiecki J, Hoppin JA, Silverman DT, Alavanja MC. Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort. International journal of cancer. 2009 May 15;124(10):2495-500.
World Health Organization. Pesticide Residues in Food-2005: Evaluations 2005, Toxicological. World Health Organization; 2006.
Bhoi R, Mahananda MR, Pradhan A. High consumption of pesticides in agricultural fields leads to prevalence of cancer cases in rural pockets of eastern India: A case study. Environmental Quality Management. 2023 Sep;33(1):359-76.
Sai MV, Revati GD, Ramya R, Swaroop AM, Maheswari E, Kumar MM. Knowledge and perception of farmers regarding pesticide usage in a rural farming village, Southern India. Indian Journal of Occupational and Environmental Medicine. 2019 Jan 1;23(1):32-6.
Kennedy S, Kullman G, Lacasse Y, Lawson B, Malmberg P, May J, McCurdy S, Merchant J, Schenker MB, Myers J, Christiani D. Respiratory health hazards in agriculture. American journal of respiratory and critical care medicine. 1998 Nov 1;158(5):S1-76.
Fareed M, Pathak MK, Bihari V, Kamal R, Srivastava AK, Kesavachandran CN. Adverse respiratory health and hematological alterations among agricultural workers occupationally exposed to organophosphate pesticides: a cross-sectional study in North India. PloS one. 2013 Jul 25;8(7):e69755.
Casida JE, Durkin KA. Neuroactive insecticides: targets, selectivity, resistance, and secondary effects. Annual review of entomology. 2013 Jan 7;58(1):99-117.
Richardson JR, Fitsanakis V, Westerink RH, Kanthasamy AG. Neurotoxicity of pesticides. Acta neuropathologica. 2019 Sep 1;138:343-62.
Nair A, Dureja P, Pillai MK. Aldrin and dieldrin residues in human fat, milk and blood serum collected from Delhi. Human & experimental toxicology. 1992 Jan;11(1):43-5.
Silva MH, Gammon D. An assessment of the developmental, reproductive, and neurotoxicity of endosulfan. Birth defects research part b: developmental and reproductive Toxicology. 2009 Feb;86(1):1-28.
Meenakshi JR, Panneer S. Occupational health of agricultural women workers in India. Indian Journal of Community Medicine. 2020 Oct 1;45(4):546-9.
Nickerson K. Environmental contaminants in breast milk. Journal of midwifery & women's health. 2006 Jan 1;51(1):26-34.
Rupa DS, Reddy PP, Reddi OS. Reproductive performance in population exposed to pesticides in cotton fields in India. Environmental research. 1991 Aug 1;55(2):123-8.
Sengupta P. Environmental and occupational exposure of metals and their role in male reproductive functions. Drug and chemical toxicology. 2013 Jul 1;36(3):353-68.
Mokarizadeh A, Faryabi MR, Rezvanfar MA, Abdollahi M. A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences. Toxicology mechanisms and methods. 2015 May 4;25(4):258-78.
Gangemi S, Merendino RA, Guarneri F, Minciullo PL, DiLorenzo G, Pacor M, Cannavo SP. Serum levels of interleukin‐18 and s‐ICAM‐1 in patients affected by psoriasis: preliminary considerations. Journal of the European Academy of Dermatology and Venereology. 2003 Jan;17(1):42-6.
Damalas CA. Understanding benefits and risks of pesticide use. Sci. Res. Essays. 2009 Oct 1;4(10):945-9.
Rakesh PS, Ankita P, Annie MC, AshutoshMasih EM, Geethu Rachel GS, Jayajiwan Simon JT, Schilling P, Lombi KM, Alex R, Balraj V, Mohan VR. Chemical use in farming and its health and environmental implications in a rural setting in southern India. IOSR J Environ Sci. 2017;11:90-5.
Zvonko32 B, Marijana33 Ć, Ivan34 S. Assessment of the socio-economic impact of the chemicals environmental contamination. Faculty of Business Economics and Entrepreneurship. 2015(1-2):113.
Hazarika R. Effect of occupational exposure of pesticides on health of farmers of the agricultural fields of Sorbhug area of lower Assam. Nature, Environment and Pollution Technology. 2011 Jun;10(2):237-41.
Kole RK, Banerjee H, Bhattacharyya A. Monitoring of market fish samples for Endosulfan and Hexachlorocyclohexane residues in and around Calcutta. Bulletin of Environmental Contamination & Toxicology. 2001 Oct 1;67(4).
Wiser GM, Magraw Jr DB. Principles and approaches of sustainable development and chemicals management for a strategic approach to international chemicals management (SAICM). Center for International Environmental Law (CIEL). 2005 Jul.
Prakash M, Donthi NR. Pesticides regulations in India and the need for protection against health risks.
Birthal PS. Economic potential of biological substitutes for agrochemicals. New Delhi: National Centre for Agricultural Economics and Policy Research; 2003.
Utyasheva L, Bhullar L. Human rights perspective on pesticide exposure and poisoning in children: A case study of India. Health and human rights. 2021 Dec;23(2):49.
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