Prognostic Relevance of Serum Ferritin on Short Term and Long term Outcome In Patients With Acute Myocardial Infarction

Editor's Note: This article has been retracted as of January 2026 as it is out of scope

Abstract

Objective-Over the decades coronary artery disease appears to be an emerging cause of mortality and
morbidity. Elevated serum ferritin as a risk factor for development of AMI. However its role with regard to
outcome and prognosis of AMI still remains a matter of debate. Hence, the present study was aimed to
estimate the prognostic relevance of serum ferritin in relation to short term and long term survival outcomes in
patients with AMI.
Methods- Out of a total number of 100 patients,with first AMI (50 of STEMI & 50 of NSTEMI diagnosis)
admitted within 12 hours of the onset of chest pain to coronary care units at MKCG Medical
College&Hospital over a period of 1 year. Serum ferritin was measured using an ELISA assay by a special kit.
The patients were divided into three groups according to Serum ferritin level.i.e.(1sttertile:<120 ng/ml,2nd
tertile:120 to 220 ng/ml and 3rd tertile:>220 ng/ml).Baselinecharacteristics,LVEjection Fraction, Killip
functional class and outcomes were compared among three different groups of serum ferritin.
Results:There was a significant correlation between serum ferritin and LV ejection fraction(p=0.01),Killip
class(p=0.03) and mortality(p=0.03). Lower and higher levels of ferritin (1st and 3rd tertiles, ≤ 120; >220 ng/ml,
respectively) were associated with a higher incidence of HF during hospitalization and death at 1 year.
Conclusion:Raised serum ferritin is associated with worse short term and longterm outcome following
myocardial infarction.