Clinico-epidemiological Profile of Paraquat Poisoning in Children at a Tertiary Care Centre: Case Series

Abstract

Aims and objectives: This case series is done to know the Clinico-epidemiological profile of paraquat poisoning
in children and also the implication of available treatment guidelines in improving outcomes in the paediatric
population as there are no standard treatment guidelines available.
Materials and Methods: Nine children were selected during the study period of October 2021 to February 2023,
demographic data were collected, clinical parameters were assessed with details such as time of presentation,
symptoms and first aid received, laboratory parameters such as LFT, RFT, chest radiographs obtained and serial
values monitored. Treatment as per the available recommendation was initiated with immunosuppressive therapy
and haemodialysis on a case-to-case basis.
Results: Among the 9 children, there were 6 females (67%) with an average age group of 15–18 years. eight (89%)
of the 9 children developed acute renal failure. Seven children underwent haemodialysis. Five (55%) children
developed hepatic dysfunction. Among the 9 children, 3 (67%) survived.
Conclusion: The study reveals that the mortality rate can be reduced, if the child presented to the hospital within
8 hours of ingestion of the compound, amount ingested is less than 20 ml, and early initiation of Haemodialysis
within 8 hours and a trail of immunosuppressive therapy.