Significance of PD-L1 Expression and Tumor Infiltrating Lymphocytes in High Grade Serous Ovarian Cancer: Egyptian Experience

Authors

  • Mai Gad1, Amany Abou-Bakr2, Rasha Mahmoud Allam3, Hanan Ramdan Nassar4, Maher H. Ibraheem5, Soha Talima6, Ghada Mohamed7

DOI:

https://doi.org/10.37506/ijphrd.v11i1.1226

Keywords:

PD?L1, HGSOC, TILS, CD4, CD8, Survival, Egypt.

Abstract

We aimed in this study to detect the correlation between PD-L1 and TILs, and their relationship with clinical outcome and survival in Egyptian patients with HGSOC. Immunohistochemical expression of PD-L1, CD4 and CD8 was investigated in 94 HGSOC Egyptian patients. PD-L1 immunoreactivity was detected in 24% of the cases. The lack of tumor PD-L1 expression proved to be an independent predictive factor for better overall survival (OS) (p= 0.01). Moreover, high stromal CD8+ TILs density had a significant impact on better disease-free survival (p=0.007). Patients who showed negative expression of PD-L1 and high intraepithelial CD8+ TILs density lived significantly longer than other patients (p- 0.021).

Author Biography

  • Mai Gad1, Amany Abou-Bakr2, Rasha Mahmoud Allam3, Hanan Ramdan Nassar4, Maher H. Ibraheem5, Soha Talima6, Ghada Mohamed7

    1Assistant Lecturer, Department of surgical Pathology, National Cancer Institute, Cairo University, 2Professor, Author, National Cancer Institute, Surgical Pathology Department, Cairo University, 3Lecturer, Author, Biostatistics and Cancer Epidemiology Department National Cancer Institute,Cairo University, Egypt, 4Professor, Medical Oncology Department, National Cancer Institute, Cairo University, 5Lecturer, Surgical Oncology Department, National Cancer Institute, Cairo University, 6Assistant Professor, Clinical Oncology Department (NEMROCK), Faculty of Medicine, Cairo University, 7Lecturer, National Cancer Institute, Surgical Pathology Department, Cairo University

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Published

2020-01-31

Issue

Vol. 11 No. 1 (2020): Indian Journal of Public Health Research & Development

Section

Articles

How to Cite

Significance of PD-L1 Expression and Tumor Infiltrating Lymphocytes in High Grade Serous Ovarian Cancer: Egyptian Experience. (2020). Indian Journal of Public Health Research & Development, 11(1), 1718-1724. https://doi.org/10.37506/ijphrd.v11i1.1226