Evaluation of Levels of Estrogen and Progesterone Hormones in Women with Preeclampsia

Abstract

Introduction: Preeclampsia was defined as new onset hypertension after 20 weeks’ gestation such that

systolic blood pressure of ?140 mm Hg, diastolic pressure of ? 90 mm Hg or both were measured on

two occasions ? 6 hours apart, with significant proteinuria (300 mg/24 h). Preeclampsia is a transient but

potentially dangerous complication of pregnancy that affects 3 to 5 percent of pregnant women.

Aims and Objectives: To study the comparison of estrogen and progesterone levels in women with

preeclampsia and without preeclampsia.

Material and Method: The present study was conducted in the department of biochemistry in collaboration

with department of gynaecology in MMIMSR, MMDU Mullana, Ambala. 100 pregnant women visiting

in MM superspeciality hospital were considered in our study. They were divided into 2 groups. Group I

included 50 hypertensive pregnant women and Group II included 50 healthy pregnant women.

Biochemical investigation: Estimation of Serum 17-? E2 (estradiol) and Progesterone were done by ELISA

Method.

Results: The mean Estradiol level were significantly lower (P<0.001) in study group (36.1±6.9) than in

control group (64.8±8.2) and Progesterone levels were significantly lower (p=0.01) in the study group (77.3

± 10.4) than in control group (113.7 ± 11.38).

Conclusion: Levels of Estrogen and progesterone were pathologically and significantly lower in preeclamptic

cases than control women with similar age, gestational age and body mass index. This difference indicates a

role of progesterone and estrogen in the pathogenesis of preeclampsia. Therefore estrogen and progesterone

levels should be evaluated in all pregnant women so as to manage these patients timely and prevent

preeclampsia.