Post-Menopausal Sex Hormones in Relation to Type 2 Diabetes  Mellitus

Authors

Priya Alva1 , Shilpa Shetty2 , Aditi Bhandary3 , Laxmi Manjeera4 , Neetha Nandan5 , Suchetha Kumari6

SHBG, Estradiol, Testosterone, DHEA, Post- Menopausal women, Diabetes Mellitus.

Sex Hormone binding globulin is a glyco protein that transports the sex steroids to their target tissue. The

concentration of free steroids in the circulation depends upon the availability of serum SHBG. Low SHBG

is associated with hyperinsulinemia, T2DM, and cardiovascular risk. Objective: The objective of the study

was to determine the correlation of SHBG with hormone levels, insulin and BMI in post- menopausal

women with type 2 diabetes mellitus (T2DM). Research Design and methods: One hundred and five post

menopausal women with diabetes and eighty five postmenopausal women without diabetes were recruited

for the study. Height, weight, BMI, was measured. Insulin,SHBG and sex steroids were measured by enzyme

linked immunosorbent assay (ELISA). Results: The mean concentration of SHBG was higher in control

group 25.21 (16.1- 43.7), than the diabetic postmenopausal women 20.65 (12.54-33.46) p<0.05. A significant

inverse association was observed between insulin resistance, free testosterone and BMI. Conclusion: In

postmenopausal women with type 2 diabetes mellitus low levels of SHBG is observed which shows an

inverse correlation with insulin resistance, free testosterone and DHEA leading to hyperandrogenecity and

hyperinsulinemia .