Clinical Profile of 46 Non AMD CNVM and Management with Anti-Vegf

Abstract

Aim: To know clinical profile of non AMD CNVM in context to (Type, location, FFA , OCT characteristics

Demography, incidence, causes)

To know clinical response to Anti-VEGF, conventional or PRN

Result:- Type: -14(30.4%) Myopic cnvm, 11(23.9%) Idiopathic cnvm, 9(19.5%) PFT, 4(8.7%) Inflammatory,

3(6.5%), choroidal osteoma with cnvm, 2(4.3%) Angiod streak, 2(4.3%) CSR with cnvm, 1(2.2%) Traumatic

cnvm.

Location: - Extrafoveal (2), juxta foveal (14), Sub foveal (27), Peripapillary (1) (Angiod streak), Unifocal

(42), multifocal (3) (PFT)

FFA:- 39(84.7%) classic, 4(8.7%) Occult cnvm, 3(6.5%) were undifferentiated. CT:-21(45.6%) type-

2 membrane, 9(19.5%) undifferentiated, 2(4.4%) type -1 membrane Demography:-Average age 49.6

yrs,range ( 20 – 64 yrs );Male preponderance, M:F ratio is 1.3:1,Almost all had unilateral presentation

except PFT (parafoveal telangiectasias) and myopic CNVM which bilateral.

Interpretation: - 6 cases responded to single dose. 10 responded to second dose of anti VEGF and 21

responded to 3rd dose. 9 were not responders to 3 dosages, given option of PDT with anti-VEGF. 2 cases

responded to PDT. 1 case responded to high dose steroids with anti-Koch’s in inflammatory CNVM. 4 cases

remain non responded to treatment. 31(67%) had improvement in vision, 8(18%) had stable vision, while

7(15%) had deteriorated.

Conclusion: - Myopic CNVM cases showed 100% response after 1 to 3 dosages of anti-VEGF.Non-AMD

cnvm cases respond well to anti VEGF alone, few more respond to added PDT.Inflammatory CNVM require

high dose steroid