Efficacy of Garlic Pill Supplementation as Adjunctive Therapy for Managing Pre-hypertension in Working Professionals: An Experimental Study
Main Article Content
Abstract
Introduction: This study delves into the effectiveness of adjunctive therapy utilizing garlic pills (Allium Sativum) among
hospital employees in the prehypertensive stage. It aims to address the heightened risk of prehypertension progressing
to hypertension, cardiovascular diseases, and stroke. Moreover, this study aims to enhance public awareness regarding
the potential use of garlic pills for blood pressure management, offering professional guidance and advocating for further
exploration of adjunctive therapy.
Methods: Employing a pre-experimental one-group Pretest-Posttest design grounded in Von Bertalanffy’s General System
Theory, the research involves 100 prehypertensive hospital staff members aged 25 to 65, selected through convenience
sampling. Over a period of six months, data collection includes baseline assessments and three months of daily intake of
500 mg garlic pills. Results: Significant mean differences in various clinical parameters are evident in the primary findings,
affirming the efficacy of garlic pills in blood pressure regulation. Posttest scores are further examined in correlation
with demographic variables such as gender, marital status, education level, and lifestyle characteristics. Overall, postintervention
data reveal promising results, with 47% of individuals with moderate hypertension and 52% of those with
mild hypertension demonstrating positive outcomes.
Conclusion: Garlic pill adjunctive therapy emerges as a potentially effective approach for blood pressure reduction, with
lifestyle modifications recommended as complementary measures for optimal prehypertension control.
Article Details
Section

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
References
Alhazmi A, Hawash MM, Ali H, Narapureddy BR, Aziz
F. Knowledge, attitudes, and practices related to dietary salt among older adults in Abha, Saudi Arabia. J Health PopulNutr. 2024;43:53. doi:10.1186/s41043-024-00545-z
Chakma T, Kavishwar A, Sharma R, Rao P. High prevalence of hypertension and its selected risk factors among adult tribal population in Central India. Pathog Glob Health. 2017;111:343–50. doi:10.1080/20477724.20 17.1396411
Gherasim A, Arhire LI, Nită O, Popa AD, Graur M, Mihalache L. The relationship between lifestyle components and dietary patterns. Proc Nutr Soc. 2022;79(3):311–23. doi:10.1017/S0029665120006898
Iqbal AM, Jamal SF. Essential Hypertension [Internet]. StatPearls. StatPearls Publishing; 2024 [cited 2025 Apr 12]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK539859/
Ismail S, Stanley A, Jeemon P. Prevalence of multimorbidity and associated treatment burden in primary care settings in Kerala: A cross-sectional study in Malappuram District, Kerala, India. Wellcome Open Res. 2022;7:67. doi:10.12688/wellcomeopenres.17674.2
Kar SS, Selvaraj K, Ramaswamy G, Premarajan KC, Saya GK, Kalidoss V. High Prevalence of Prehypertension and its Association with Modifiable Risk Factors: Findings of Household STEPS Survey from Urban Puducherry, South India. Int J Prev Med. 2020;11:162. doi:10.4103/ijpvm.IJPVM_6_19
Kurjogi MM, Vanti GL, Kaulgud RS. Prevalence of hypertension and its associated risk factors in Dharwad population: A cross-sectional study. Indian Heart J. 2021;73(6):751–3. doi:10.1016/j.ihj.2021.10.006
Longkumer I, Yadav S, Rajkumari S, Saraswathy KN. Trends in hypertension prevalence, awareness, treatment, and control: An 8-year follow-up study from rural North India. Sci Rep. 2023;13:9910. doi:10.1038/s41598-023-37082-4
Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223. doi:10.1038/s41581-019-0244-2
Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223–37. doi:10.1038/s41581-019-0244-2
Mohseni-Takalloo S, Mozaffari-Khosravi H, Mohseni H, Mirzaei M, Hosseinzadeh M. Evaluating Neck Circumference as an Independent Predictor of Metabolic Syndrome and Its Components Among Adults: A Population-Based Study. Cureus. 2023;15(6):e40379. doi:10.7759/cureus.40379
Rafan SN, Zakaria R, Ismail SB, Muhamad R. Prevalence of prehypertension and its associated factors among adults visiting outpatient clinic in Northeast Malaysia. J Taibah Univ Med Sci. 2018;13(5):459–64. doi:10.1016/j. jtumed.2018.06.005
Rahut DB, Mishra R, Sonobe T, Timilsina RR. Prevalence of prehypertension and hypertension among the adults in South Asia: A multinomial logit model. Front Public Health. 2023;10:1006457. doi:10.3389/fpubh.2022.1006457
Ried K. Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis. Exp Ther Med. 2020;19(2):1472–8. doi:10.3892/etm.2019.8374
Rippe JM. Lifestyle Strategies for Risk Factor Reduction, Prevention, and Treatment of Cardiovascular Disease. Am J Lifestyle Med. 2018;13(2):204–12. doi:10.1177/1559827618812395
Sarma PS, Sadanandan R, Thulaseedharan JV, Soman B, Srinivasan K, Varma RP, et al. Prevalence of risk factors of non-communicable diseases in Kerala, India: Results of a cross-sectional study. BMJ Open. 2019;9(11):e027880. doi:10.1136/bmjopen-2018-027880
Serrano JCE, Castro-Boqué E, García-Carrasco A, Morán-Valero MI, González-Hedström D, Bermúdez-López M, et al. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. Nutrients. 2023;15(17):3691. doi:10.3390/nu15173691
Shang A, Cao S-Y, Xu X-Y, Gan R-Y, Tang G-Y, Corke H, et al. Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.). Foods. 2019;8(7):246. doi:10.3390/foods8070246
Singh S, Shankar R, Singh GP. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. Int J Hypertens. 2017;2017:5491838. doi:10.1155/2017/5491838
Srivastava A, Mirza TM, Vaqar S, Sharan S. Prehypertension [Internet]. StatPearls. StatPearls Publishing; 2024 [cited 2025 Apr 12]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK538313/
Tan JL, Thakur K. Systolic Hypertension [Internet]. StatPearls. StatPearls Publishing; 2024 [cited 2025 Apr 12]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK482472/
Vijna, Mishra CP. Prevalence and predictors of hypertension: Evidence from a study of rural India. J Family Med Prim Care. 2022;11(3):1047–54. doi:10.4103/jfmpc.jfmpc_967_21
Varshney R, Budoff MJ. Garlic and heart disease. J Nutr. 2016;146(2):416S–421S. doi:10.3945/jn.114.202333.
Press Trust of India. 1 in 3 suffering from prehypertension in India: ICMR study. The Week [Internet]. 2024 Mar 21 [cited 2025 Apr 12]; Available from: https://www. theweek.in/wire-updates/national/2024/03/21/del108-health-icmr-prehypertension.html