The harmful Effects of Monosodium Glutamate on Blood Parameters Liver and Kidney Functions In Adult White Rats and the Protective Role of Omega-3

Abstract

The present study was conducted to find out the harmful effect of exposure to monosodium glutamate
(MSG) on laboratory animal weight, hematological and biochemical parameters on rats of 10 -15 weeks
old and weight of 100-200 g. Whereas, this study was conducted in the Basic Sciences Branch - College of
Nursing - University of Warith Alanbiyaa From 11/1/2019 to 2/1/2020, the animals were divided into four
groups
G 1- Control The first group control
G 2- MSG (1.8mg / kg) Group II
G 3 - MSG (1.8 mg / kg) + omega-3 (0.8 mg / kg) Group III
G 4 - MSG (1.8 mg / kg) + omega-3 (1.2 mg / kg) Group IV
Where the four groups were fed according to
The above distribution is according to the concentrations in each group effect of MSG at one oral low dose
of 1.8 mg/g body wt. on liver and kidney functions in albino rats. The possible protective effect of omega
3 (at oral dose of 0.8 mg/g body wt.) (at oral dose of 1.2 mg/g body wt.) against MSG induced hepatic and
renal stress was also investigated of mono-sodium glutamate for 30 days.
The results showed a significant decrease (p <0.05) in blood parameters, including RBC count 5.1 ±0.7 and
concentration of PCV: 14.5 ±0.33, MCH: 34.5 ± 2.77, MCV: 96.5 ±3.21, MCHC: 34.0 ± 0.89. Compared
with the control group indicating anemia in MSG treated animals.
There was a significant increase in the biochemical parameters (AST: 216 ± 14.8, ALT 3.6 ± 0.40, ALP144.75
± 6.55). And also in the Urea - Creatinine kidney standards
Which represents the liver function in animals treated with monosodium glutamate compared with the
control group, despite a significant increase (P <0.05) in the level of urea 2.70 ± 0.07 and creatinine 0.098 ±
0.005 in the blood in the animal treated with MSG compared with the control group.