Assessment the Role of Ubiquinone (Coenzyme Q10) against Spermatotoxic Effect of Busulfan in Male Rats

Abstract

Busulfan is a chemotherapy treatment for cancer patients, and in comparison with the coenzyme ubiquinone
is a coenzyme that works to enhance chemical reactions and protect the body from free radicals. It helps in
treating cancer and protecting patients undergoing chemotherapy. This study was aimed to investigate the
role of ubiquinone against the toxic effect of busulfan on sperm in adult white rats for a period of time, and
the experiment was carried out for eight weeks on 24 male adult rats were used, the study was conducted
in periods (day 28 ). Distributed in four groups randomly and equally in each group of 6 male rats. The
control group injected with distilled water intraperitoneally , second group were injected with busulfan
(chemotherapy) only one dose of 10 mg / kg. while animals of third group injected with single dose of
busulfan 10 mg / kg plus coenzyme ubiquinone COQ10) 10 mg / kg ) for 4 weeks, while animals in fourth
group were injected with the coenzyme ubiquitin coenzyme (COQ10) 10 mg / kg for 4 weeks. At the end
of experiment the blood was collected for measuring of blood parameters and hormones levels and sperm
analysis has benn done