Review: Cancer Cells Resistance Strategies

Abstract

Cancer, which is the most important health problem, develops the ability to resistant traditional medications
this leads to increase efforts to develop new cancer medication protocols. In this review, the chemotherapy
resistance could be due to several mechanisms. These mechanisms involve either inactivation by two
important phases, phase I which involve oxidation, reduction and hydrolysis or phase II which involve
conjugation wi, alteration of the target site which decrease either activation of anticancer prodrug and/or
decrease its influx to cancer cells. Other mechanisms for chemotherapy resistance return to the repairing
of cancer cell DNA, modulation of efflux for drug, inactivation of apoptosis, besides how the role of
heterogeneity of tumor cells in drug resistance. All of these strategies obligated the oncologist to use a
combination of chemotherapy medication to overcome or avoid resistances to treatments.